Integrins and matrix in the glomerulus: old mysteries and new insights.

نویسنده

  • Jordan A Kreidberg
چکیده

on how to write a scientific paper. Given the experience of the organizers with similar hands-on courses, both at MDIBL and elsewhere, we believe the training in this course will strengthen the research of participants, enhance their potential as future investigators, and effectively reach others. We are hopeful that graduates will also contribute to the teaching of mechanisms of fluid and electrolyte disturbances at our national medical centers. Fellows interested in taking the course and their fellowship directors can log on to the course website for further information: http:// www.mdibl.org/courses/renal08.shtml.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ovarian Stimulation by Exogenous Gonadotropin Decreases the Implantation Rate and Expression of Mouse Blastocysts Integrins

Background: Integrins are heterodimeric glycoprotein receptors that regulate the interaction of cells with extracellular matrix and may have a critical role in implantation. The aim of this study was to investigate the effect of ovulation induction on the expression of α4, αv, β1, and β3 integrins in mouse blastocyst at the time of implantation. Methods: The ovarian stimulated and non-stimulate...

متن کامل

CD147 (Extracellular Matrix Metalloproteinase Inducer-EMMPRIN) Expression by Human Articular Chondrocytes

Background: Integrins are a family of transmembrane proteins that allow communication between the extracellular matrix and the interior of cells. Chondrocytes, cells of articular cartilage, express integrins and these molecules appear to have a variety of roles including mechanotransduction. Integrins are known to associate with a number of accessory molecules such as CD147 that may act to regu...

متن کامل

Integrin α2-deficient mice provide insights into specific functions of collagen receptors in the kidney

BACKGROUND Integrins are important cellular receptors for collagens. Within the glomerulus, podocytes regulate the integrity of the glomerular basement membrane (GBM) by sensing the presence of collagen and regulating collagen IV synthesis. The present study evaluates the role of integrin α2 (ITGA2) in cell-matrix interaction. METHODS AND RESULTS ITGA2-deficient mice had normal renal function...

متن کامل

New insights into the prevention and treatment strategies for hypertrophic scars and keloids

Hypertrophic scars and keloids are fibrosis abnormalities associated with the accumulation of collagen and extra cellular matrix components. These scars are caused by abnormal wound healing, which may occur after skin injuries caused by surgery, trauma, burns, etc. and may have a large impact on the patients’ quality of life. Hypertrophic scars and colloids in addition to aesthetic problems can...

متن کامل

β1-integrins and glomerular injury

The renal glomerulus is composed of three types of glomerular cells (mesangial cell (MC), endothelial cell and podocyte) and extracellular matrix (ECM) consisting of the glomerular basement membrane (GBM) and mesangial matrix. It constitutes ahighly specialized microcirculation in which the permeability characteristics of the capillary wall allow its unique filtrationfunction.Theproliferationof...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of the American Society of Nephrology : JASN

دوره 19 4  شماره 

صفحات  -

تاریخ انتشار 2008